MOL- Molisa GmbH - Small and medium-sized enterprise

Organisation description

General description:

MOLISA is a high tec based company devoted to the discovery and development of novel pharmaceutical entities and was founded in 2002 in Magdeburg. The complementary expertises of the founders, Prof. Dr. Dieter Schinzer and Prof. Dr. Dr. h.c. Leopold Flohé, cover most of the technical disciplines required for the discovery and development of novel drugs.

The general goal of MOLISA is the identification of novel pharmaceutical entities which are a priori defined by their mechanism of action and posses optimum pharmacokinetic characteristics ("small molecules"). The product finding concepts arose from the research groups of the founders and are exploited by MOLISA. They aim at diverse therapeutic areas, which imply the necessity to consider alternative strategies of development and commercialization. A homogeneity of the product opportunities exist so far as they can all be developed up to a commercially attractive level by MOLISA-specific technology. The developments currently in progress aim at the following fields of application:

Infections by

Trypanosoma species (Chagas disease; Sleeping sickness),
Leishmania species (Kala Azar and related diseases),
Plasmodia species (Malaria),
Mycobacteria (tuberculosis),
Malignant diseases,
Control of male fertility.

In addition, MOLISA offers contract synthesis to pharmaceutical companies in order to generate extra cash flow. This business has increased over the last few years and at the moment MOLISA has 12 employees and has just moved to a new site with brand new
chemistry and biology labs.

Expertise

organic (classical / asymmetrical) natural product synthesis
synthesis of biologically active / pharmaceutically interesting compounds
expertise in pre-pharmaceutical chemistry and lead structure development
estimation of the industrial importance of substance candidates
custom research/development and organic synthesis to business partners
development of proprietary lead structures
target production and biological testing

Facilities

NMR,
FT-IR,
MS,
X-Ray

Other European projects the organisation has been involved in:

---

Role in the project

Chair of WP1, participation in WP2, WP6
Key personnel involved in INTENANT
Prof. Dieter Schinzer, Dr. Oliver Böhm