UNIMAN - University of Manchester - Research Organisation

Organisation description

General description:

General description: University of Manchester is one of the largest higher education
institutions in the UK with in excess of 30,000 students across 5 faculties. This project is
located within the School of Chemical Engineering and Analytical Science. The School has
55 academic staff members with background training in chemistry, chemical engineering,
biology and physics and an annual research income of close to £15M.

Expertise

We have an international reputation for our work on crystal polymorphism,
nucleation and crystallization, and long experience in the design of selective additives for
control of crystallization kinetics and in the use of solvents to control both morphology and
crystal phase. We recently demonstrated the combined use of ternary phase diagrams and
crystallization additives to give chirally enriched products in a racemic compound forming
systems. We are intensively collaborating with UR on crystallization, ternary phase
behaviour and oiling out, and with ASTRAZENECA on salt formation and polymorphism.

Facilities

NMR, FT-IR, Raman, UV/vis, MS, powder and single crystal diffraction, DSC.
Role in the project

Other European projects the organisation has been involved in:

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Role in the project

Participates in WP4.
- Crystal structure determination of new compounds,
- Measurement of phase equilibria in ternary enantiomeric systems,
- Crystallization in various regions of phase diagrams & measurement of nucleation rates,
_ Design of additives to inhibit the nucleation of unwanted phases.

The expertise at Manchester exactly compliments that at ETHZa (Prof. Mazzotti) and at UR
(Prof. Coquerel). In particular, the expertise of Prof. Davey provides a link between kinetic
measurements of nucleation in various areas of phase space and solute-solvent interactions.
It allows manipulation of nucleation and growth rates of various phases by solvent
selection and additive design.

Key personnel involved in INTENANT
Prof. Roger Davey (Director of the Molecular Materials Center, University of Manchester)

Link

http://www.manchester.ac.uk